Objective. This descriptive, transverse study, attempts to establish the existent relation between the degree of perceived pain, anxiety, depression and quality of life of elderly hospitalized patients. Method. A stratified1 Licenciado en Psicologia. Agencia de Evaluacion de Tecnologias Sanitarias de Andalucia (Aetsa). Avda. Luis Montoto, 89, 4a planta. CP: 41007 Correspondencia: juanm.molina.ext@juntadeandalucia.es 2 Psicologa, Doctora en Psicologia Clinica y de la Salud. Grupo de Investigacion, Psicologia Clinica y de la Salud. 3 Doctoranda en Psicologia Clinica de la Pontificia Universidad Catolica de Puerto Rico, Ponce. Grupo de Investigacion, Psicologia Clinica y de la Salud. Pontificia Universidad Bolivariana, Seccional Bucaramanga. JUAN MAXIMO MOLINA LINDE, ANA F. URIBE RODRIGUEZ, JANICE FIGUEROA RODRIGUEZ 44 random sample was used for this study. Using the Goldberg Anxiety and Depression Scale (GADS), the Nottingham Health Profile (NHP), and the Simple Verbal Scale (SVS), the patients’ reported anxiety and depression levels, as well as the intensity of their pain were measured. Results. It was observed that in general, as the patient’s pain increased, their depression and anxiety levels, and the quality of life areas evaluated using the NHP, worsened. Analyses are descriptive and inferential. Conclusion. In view of the deterioration of the quality of life and its relationship to the emotional responses associated with anxiety and depression, and the intensity of pain, interventions should be carried out at primary and secondary level to permit pain control, in order to reduce the impact on the mental health of older adults, based on pharmacological and psychological integrated strategies. Likewise, it is suggested that inpatient programs incorporating holistic therapies which, in turn, meet the emotional affective elderly needs of hospitalized patients, are created, with the aim of improving their quality of life.