We conducted a literature review and revised museum collections, as well as original datum of the authors, to create a list of the gastropod and bivalve freshwater and estuary mollusk for the venezuelan Orinoco basin. We consolidated a preliminary list of 104 species distributed between the Gastropod (14 families and 58 species) and Bivalve classes (13 families and 45 species). For the gastropods, the Ampullaridae family was the most diverse (22 sp.) and for the bivalves, the Mycetopodidae family (16 sp). In the list, we include the geographic distribution in the Orinoco watershed, as well as information on their local use, their sanitary importance, ecological habitat and the type of substrate associated for each species.