This article proposes a theoretical model to generate a strategic change in the mode of action concerning the university entrepreneurship Manizales. The proposed model is based on Interviews with key informants and experts as well as the literature review of experiences and existing models. The need to promote innovative entrepreneurship from the base of undergraduates lets to conclude on the relevance of the proposal, not only by the gap, but by the willingness of the city to become an entrepreneurial ecosystem where the IES are called to be protagonists.