Low back pain is a very common reason for consultation in general practice; due to the wide offer of treatment options, it is important, in order to select the best, to resort to the concepts of evidence-based medicine. The interventions that have more solid evidence in the literature are: to keep being active, to prescribe therapeutic exercises during the subacute and chronic periods, as well as after surgery, and to use nonsteroidal antiinflammatories and antidepressants.