The cleft lip and / or palate are part of craniofacial congenital abnormalities or genetic trait, affect the structures of the oral cavity and the palatal vault. Objective: To the Cleft characterize Lip and Palate, serving Operation Smile Colombia Foundation in Cartagena de Indias. Methodology: Sample type targeted was conducted, the total number of patients treated by Operation Smile Colombia Foundation in the years 2011-2013 that are linked to the National Comprehensive Care Program, through an analysis of frequency distribution was taken, the variables under study were the age, gender and demographic location. Results: The age of 0-2 years old, presented a frequency of 21.9%, there were no differences in gender distribution,socioeconomic status more prevalence in class 1 that was 56.3%. Regarding the geographic variable, it was determined that the Industrial Bay Area, the cleft lip and palate had a higher prevalence, with a frequency of 43.7%. Conclusions: We showed that this condition is more common in socioeconomic classes 1 and 2, which contain a high proportion of vulnerable population compared to other class.