This paper presents a proposal for the development of academic activities using collaborative hypermedia environments that allow synchronous communication and interaction. This proposal emerged as an initiative of a group of people concerned for successfully moderating video-conferences with e-presenters from all over the world in order to reunite different experts and people sharing the same interests to generate knowledge. The moderation of these video-conferences, through five major online events, led to the creation of an e-moderation team that planned, coordinated and monitored all video-conferences. This document, collaboratively created and edited, provides a guide for organizing virtual events. Additionally, this document offers a proposal for e-moderators to logistically, pedagogically, managerially, socially and technically assist e-speakers during their e-presentations. In this paper, we present guidelines for moderating video-conferences, including e-moderators' roles. The results that derived from the analysis of participants' feedback are shown. We also include a section describing the most common technical problems that may hinder the successful development of video-conferences. Finally, we give some recommendations to e-moderators to effectively organize, plan and manage online video-conferences.