En el presente estudio prospectivo se evaluo el gluconato de clorhexidina al 0.2 % (Plako' SM.R) como agente preventivo de complicaciones orales en doce pacientes con leucemia linfoide aguda en fase seis de remision. Cada sujeto fue su propio control, registrandose el indice de placa de Loe (1967) y el indice gingival de Silness y Loe (1963) antes del uso del enjuagatorio, durante su uso (10ml. por 30 segundos una vez al dia) y luego de la suspension de este. Se pudo observar que los promedios para ambos indices fueron muy bajos (0.1 a 1.0) desde el inicio del estudio. El indice gingival aumento levemente durante el periodo de prueba del enjuagatorio y luego disminuyo. Se presentaron diferencias altamente significativas al comparar las tres etapas del estudio para los dos indices, excepto al comparar la etapa inicial y la final del indice gingival. Sin embargo, en sujetos con leucemia linfoide aguda en fase seis de remision no se justificaria el uso de clorhexidina desde un punto de vista clinico debido a su buen estado periodontal. Abstract The prophylactic value of once-daily mouth rinses with a solution ofO.2% chlorhexidine gluconate in minimizing plaque and gingivitis during remission chemotherapy was tested in twelve patients with acute lymphoblastic leukemia. Standardized measurement indexes were employed to assess the dental plaque levels and the degree of gingivitis. Lower average dental plaque scores and gingivitis scores were recorded over the study periodo The plaque scores were continuosly decreasing while the gingivitis scores were increasing during the second period and decreasing during the third periodo In addition, there was a statiscally significant reduction in plaque scores and gingivitis scores, but there was no statiscally significant difference between the first control and the second control in the gingival index. However, in patients with acute lymphoblastic leukemia in remission chemotherapy wouldn' t be justified the use of chlorhexidine because of their good periodontal health.