The management of Barrett's esophagus (BE) and dysplastic and neoplastic changes associated with it has changed with the recent advent of techniques such as endoscopic mucosal resection and radiofrequency ablation. These two techniques have been added to the repertoire for managing this complication of gas- troesophageal refl ux disease because of their high levels of safety combined with the rarity of complications resulting from them. We report a case of Barrett's esophagus and associated dysplasia which was managed fi rst with a sequence of mucosal resection of large lesions followed by radiofrequency ablation. Complete eradication of dysplasia and intestinal metaplasia was achieved.