Twenty healthy individuals as normal controls and 120 adults patients of both sexes were studied, distributed equally in the following clinical entities: Sepsis, Toxemia, Cancer, Post operative states, Thrombophebitis, POCD, Uraemia, Hyperlipidemia, under the effect of anticonceptive drugs, Arterial Thrombosis and Myocardial Infarction. In order to detect probable Hypercoagulability states, the following laboratory tests were performed: Thrombin time, Dosification of Fibrinogen, Fibrinogen Degradation Products (FDP), Fractions D and E of the Fibrinogen Degradations Products, Dosification of Coagulation Fraction of Factor VIII, Factor VIII Antigen, Ratio Factor VIII Antigen/Coagulation Fraction of Factor VIII and levels of Antithrombin III. In average, we found abnormalities in the following results: High levels of Fibrinogen in 66%. Fibrinogen Degradation Products abnormals in 55% for the Merskey method and 46% in the Protamine Sulfate test. Low concentration of Antithrombin III in 34%. High levels in fractions D and E of Fibrinogen Degradation Products in 33%. Increase in the Coagulation Fraction of Factor VIII in 28% and high ratio Factor VIII Antigen/Coagulation Fraction of Factor VIII in 23%. The abnormal Thrombin time only in the 17% of our patients. In the first step of the study of probable Hypercoagulability states, we found as indicatives and fesible tests from a practical point of view: The levels of Fibrinogen, the Fibrinogen Degradation Products for the Merskey method and the Protamine Sulfate test respectively, the levels of Antithrombin III, the fractions D and E of the Fibrinogen Degradation Products and the dosification of Coagulations Fraction of Factor VIII.