This article analyzes neuroimmune linguistic programming as a transversal spiritual axis in living organizations with a human face. It is based on the theories of Punset (2010), Koenig, et al. (2001) and O’Donnel (2000), among others. Methodologically, it was framed in a qualitative, documentary paradigm with a bibliographic design. Findings show studies revealing that what employees want most in their work is a feeling of love and care and some connection between their work and their larger purpose in life. From the perspective of neuroimmune linguistic programming, spirituality can be seen as a management tool for motivation in the XXIst-century leader. It helps to create a better atmosphere in the workplace. It is a vision of positive, optimistic life that improves self-esteem, serving as a transversal, spiritual axis in living organizations with a human face.