Introduction: The syndrome of external biliary compression, or Mirizzi's Syndrome, described by Pablo Mirizzi in Argentina in 1948, is an infrequent surgical entity that constitutes a real diagnostic and management challenge. Materials and Methods: Retrospective descriptive study of cases bases on the clinical records of 934 patients subjected to cholecystectomy at Hospital San Jose (Bogota, Colombia) in the period 2001-2005. Epidemiological data, surgical procedures performed, and morbidity and mortality were analyzed at this high-complexity level of care institution. Results: 36 patients had Mirizi's syndrome. According to A. Csendes' classification there were 31 (86%) patients with type I Mirizi's syndrome, 1 (2.7%) type II, 3 (8.3%) type III, and 1(2.7%) type IV, for an overall prevalence of 3.85%. Conclusion: World literature reports a prevalence of Mirizzi's Syndrome of 0.7 to 1.4%, while at Hospital San Jose prevalence was 3.85%. Our Hospital is a recognized center in the managements of biliary pathology, where surgeons achieve a high level of training, which perhaps makes improbable an overestimation of the concept and diagnosis of Mirizi's syndrome.