Objective: To determine the epidemiologic and pathological data, and the surgical end results in a series of patients that underwent cephalic pancreatoduodenectomy over a three year period at a referral center for hepatobiliary-pancreatic diseases and liver transplantation in the city of Medellin, Colombia. Methods: Information was collected in a prospective manner from the data base of the Unit of Hepatobiliary and Pancreatic Surgery at our institution. Results: Nineteen patients, 31.5% male and 68.5% female, were subjected to cephalic pancreatoduodenectomy with curative intention in the period January 2002 trough December 2006. Main indication was carcinoma of the head of the pancreas (36.8%), followed by ampullary carcinoma (21%), and neoplasms of the biliary tract and duodenum (10.5%). Morbidity rate was 47.3% and mortality rate 15%. Overall actuarial survival was 57.8%, and one-year survival was 68.5%. Discussion: cepahalic pancreatoduodenectomy is major surgical procedure, which when performed at referral center can achieve morbidity and mortality rates similar to those reported in the world literature.