Resumen Proposito : Presentar nuestra experiencia y describir las caracteristicas clinicas, los desafios quirurgicos y el resultado de la cirugia de las epilepsias en pacientes adultos y ninos. Metodo : Analisis retrospectivo de 552 cirugias de epilepsia realizadas en la Fundacion Centro Colombiano de Epilepsia y Enfermedades Neurologicas entre 1989 y 2008, de un total de 750 cirugias. Resultados : Desde 1989 hasta 2009 se han realizado 750 cirugias de epilepsia. 552 pacientes, cumplian con todos los criterios de la inclusion para el estudio en mencion. Todas las resecciones quirurgicas fueron realizadas por el mismo neurocirujano (JFF) y todos los pacientes ingresaron al mismo protocolo. El control postoperatorio de las crisis tuvo un rango de 30% al 70% dependiendo del tipo de intervencion quirurgica. La morbilidad y la mortalidad estuvieron en el orden del 1%. Conclusion : La evaluacion de los pacientes con epilepsia medicamente intratable debe estar a cargo de un grupo de especialistas en epilepsia dentro de centro especializado en cirugia de epilepsia. No hay restricciones en la edad para la cirugia de la epilepsia, ni restricciones en relacion al sindrome epileptico y el tipo de intervencion. El control de las crisis alcanza porcentajes de exito hasta del 70% en los pacientes postquirurgicos, sin embargo es variable si la meta de la cirugia es paliativa o curativa. La rehabilitacion es fundamental para la calidad de vida de estos pacientes. Nuestra experiencia fortalece la continuidad de los programas de cirugia de epilepsia. Palabras clave: Epilepsia, cirugia. Summary Object : To present the experience of a center in epilepsy surgery and to describe the clinical characteristics, surgical challenges, and outcome in epilepsy surgery. Methods : Retrospective analysis of 552 epilepsy surgeries is presented. Results : Since 1989, when we opened the epilepsy surgery program in our center, until 2009, we have operated on 750 patients for epilepsy surgery. 552 patients had all the inclusion criteria for our study. All surgical resections were performed by the same Neurosurgeon (FFJ). Every patient was studied with video-EEG and received the same protocol. Seizure control was 30% to 70% of patients after surgery and varies depending whether the procedure was a palliative o therapeutic. Operative morbidity and mortality was 1%. Conclusions : A teem of epileptologists, neurosurgeons and neuropsychologists at a center offering epilepsy surgery, should evaluate patients who are not seizure controlled after failure of two to three AEDs. Generally, the most refractory cases are those patients with symptomatic substrates, and they are often excellent surgical candidates. There are no age restrictions for epilepsy surgery, nor is epilepsy surgery restricted to a single epilepsy syndrome or type of operation. Seizure control can be expected in 50% to 70% of patients after surgery and varies by operative used technique and whether the goal of surgery was palliative or curative. The rehabilitation is crucial to the quality of life of these patients. Our experience in a transitional country, aims us to continuing with this important procedure. Key Words Epilepsy, surgical treatment