Introduction: thyroid diseases are often observed in women, which induce many alterations including cardiovascular, osteomuscular and nervous systems. Thyroid hormones have an important infl uence on stress regulate system and suggest that thyroid dysfunctions might have a complicated modulation on the stress axis. Patients and methods: aiming to observe the infl uence of hypo and hyperthyroi clinical conditions, before and after treatment in 7 hypothyroid, 7 hyperthyroid and 7 normal women as control group. Measurements: we performed ACTH and Cortisol curve of secretion after stimulation with