Objetivo: identificar, el tratamiento farmacologico mas costo-efectivo para el tratamiento de la depresion en Colombia. Poblacion: hombres y mujeres de 19 anos de edad en adelante, con diagnostico reciente de depresion, vistos en atencion primaria quienes no han recibido tratamiento previo. Alternativas comparadas: los medicamentos disponibles en el pais y de mayor frecuencia de uso en el manejo de la depresion. Objective: to identify the most cost-effective treatment for depression in Colombia. Population: women and men older than 19 years old, with a recent depression diagnosis, which were attended in primary attention and had not received any previous treatment. Compared alternatives: most frequently used and available drugs in Colombia for depression management.