This text presents to the readers the new methodology suggested for the innovation wheels, looking forward to create an innovation and entrepreneurship ecosystem around the intelligent use of science, technology and human capital in the region. The EAN University has participated in the construction of effective spaces for the encounter between the academy and the business community, in search of strengthening the negotiation skills and structuring projects. The agro-industry and services sectors have been the sectors of greater participation in both wheels, showing a special interest in innovation.