The purpose of this research was to establish the frequency of neuropsychiatric disorders in college students with poor academic achievement of San Buenaventura University in Medellin- Colombia. From a population of 300 students, a random sample of 39 subjects with academic difficulties from different undergraduate programs which corresponds to 13% of the population was taken, in order to detect disorders with a frequency upper than 2%, a confidence level of 95 % and a power of 80 %. A neuropsychiatric structured interview for adults (Mini-PLUS) was used. 61.5% did not show any neuropsychiatric diagnosis; however, 10.3% presented major depression criteria, and 10.3% suicide risk.