SUMMARY Anti-NMDA receptor encephalitis is a severe disorder with a dramatic clinical presentation, often showing a purely initial neuropsychiatric phase, and evolving into a severe encephalopathy accompanied by involuntary movements, seizures and autonomic instability; the disease course is typically prolonged and needs intensive care treatment.We report the case of a 5-year-old child, diagnosed with Anti-NMDA receptor encephalitis with immune modulatory therapy.KEY WORDS. Autoinmune encephalitis, anti-nmda receptor encephalitis (MeSH). Recibido: 05/02/14. Aceptado: 03/07/14. Correspondencia: Juan Pablo Rojas: juanpa8506@hotmail.com (1) Residente de Pediatria. Universidad Libre Seccional Cali. Fundacion Clinica Infantil Club Noel, Cali – Colombia.(2) Pediatra. Docente Universidad Javeriana Cali. Fundacion Clinica Infantil Club Noel, Cali – Colombia (3) Pediatra Intensivista. Docente Universidad Libre Seccional Cali. Fundacion Clinica Infantil Club Noel, Cali – Colombia. INTRODUCCION