One of the best known and most widely used natural colorants is that obtained from the seed of the Achiote (Annatto). In this article, the parameters -type of solvent, amount of seed, pH, and required time of agitation- needed for the design of a pilot plant to obtain the colorant, are selected through experimental design. Given these parameters, a pilot plant can be designed and its necessary equipment selected to be placed according to the corresponding flow diagram.