The medication overuse headache (MOH) is define as daily or almost daily headache (15 days or more) in patients with history of primary headache who takes excessive medications. This pathology is associated with psychiatric conditions, reason why with the time the clinical characteristics become more complex. The basic treatment is stopping the medication (analgesic, ergotamine, triptans or opioids), but this could bring us another problem called “rebound headache”, withdrawal sindrome or epileptic convulsions. These symptoms could increase the relapsing rate on this patients.