In order to identify methodologies for effective identification and incorporation of the user considerations and perspective to the development of clinical practice guidelines, a systematic review of the literature was conducted. A total of 729 articles were identified from the initial search of these, 18 met the criteria and were included in the review. The items were valued according to methodological quality and extracted relevant information from them. No methodological items were found that described or evaluated a specific methodology that incorporates considerations of the patients in the development of GPC. The techniques used for these processes were the formal ones such as Delphi, focus groups, stakeholder analysis, surveys, workshops and preference scales. The reported experiences agree on the need to link patients during the stages of prioritization and approval of the recommendations.