This Article serves as the first law review essay to engage the feminist debates regarding sex work and human rights in the African context. The Article surveys “antiprostitution” and “pro-sex-worker” feminist arguments and activities in sub-Saharan Africa; explores the debate surrounding the legal frameworks of legalization, decriminalization, prohibition, and abolition of prostitution in a number of African countries including Senegal, where prostitution is legal and regulated, and South Africa where prostitution remains illegal despite civil society advocacy for decriminalization; and calls for the empowerment of African sex workers by arguing for a human rights-based transformation in African governments' legal and policy posture towards sex work.