Se realizo la presentacion de un caso con criptococosis con localizacion en el sistema nervioso central en una paciente inmunocompetente atendida en el Hospital General de Medellin. La paciente presento un cuadro de meningoencefalitis aguda. Se demostro la causa micotica del proceso mediante estudio microbiologico del liquido cefalorraquideo. No se comprobaron otras localizaciones del hongo en el paciente. SUMMARY The case of a women inmunocompetent patient suffering from cryptoccocis with localization in the central nervous system that was attended in the General Hospital of Medellin. This patient initially had acute meningoencephalitis. The mycotic cause of the process was demonstrated by a microbiological study of the cerebrospinal fluid. No other localizations of the fungis were observed in the patient.