Introduction: atherosclerosis is an inflammatory disease in which the stability of coronary plaque and its rupture with the onset of acute myocardial infarction could be influenced by microbial infections through production of inflammatory mediators. These molecules also occur in patients with asymptomatic bacteriuria, common condition after age 65. Objective: a comparative study to determine if asymptomatic bacteriuria is associated with acute myocardial infarction was developed. Material and methods: patients over 65 with atherosclerotic coronary artery disease or patients at high risk of developing it, were included . Patients with acute myocardial infarction in two hospitals in fourth level in Medellin (Colombia) were chosen. The calculation of adjusted Odds ratio was performed using a logistic regression model. Results: 60 cases and 120 controls were studied. The mean age was 74.94 ± 7.08 years. 37 cases of asymptomatic bacteriuria among 180 patients were documented, for a prevalence equal to 20.6% with female predominance (12.4 vs 32%). The proportion of asymptomatic bacteriuria in the cases was 15% and in controls 23.3% for a crude OR of 0.58 (95% CI 0.25 1.32) and an adjusted OR of 1.31 (95% CI 0.53 3.26). Bacteriuria asintomatica como factor asociado al infarto agudo del miocardio Asymptomatic bacteriuria as a factor associated to acute myocardial infarction Jaime enrique Paillier, erik Javier TresPalacios, Jaime andres calle • Medellin (ColoMbia) Dr. Jaime Enrique Paillier: Internista. Aspirante a Magister en Epidemiologia, Universidad CES. Medico en Cuidados Intensivos, Hospital General de Medellin; Dr. Erik Javier Trespalacios: Internista-Cardiologo Clinico. Fellow en Ecocardiografia, Universidad CES, Clinica Medellin; Dr. Jaime Andres Calle: Medico, Universidad CES. Medico en Cuidados Especiales, Hospital General de Medellin. Medellin (Colombia). Correspondencia: Dr. Jaime Enrique Paillier. Medellin (Colombia). E-mail: paillier999@gmail.com paillier999@hotmail.com Recibido: 29/VII/2013 Aceptado: 1/VIII/2014