Palabras clave: Hipotension; Choque anafilactico; Choque distributivo; Envenenamiento por abejas. Abstract: MULTIPLE BEES STINGS POISONING AND SECONDARY ANAPHYLACTIC SHOCK: A CASE REPORT AND LIT- ERATURE REVIEW. Eduardo Contreras Zuniga, Sandra Ximena Zuluaga, Isabel Cristina Casas Quiroga. Acta Toxicol. Argent. (2008) 16 (2): 27-32. Less than 5% of the estimated 20,000 species of bees are social, and therefore massive attacks might occur or situations of risk could be generated when swarming to build hives near or inside homes. Bee venom consists of a mixture of substances, mainly protein enzymes, peptides and biogenic amines, these proteins have pharmacological actions and allergens can induce boxes poisoning in humans and animals. We describe the case of a farmer who suffered more than 500 stings by bees with a fatal outcome. In addition, a brief review of the literature is presented.