Neurocysticercosis is a disease of high prevalence in tropical and low-income countries and its incidence has been increased in developed countries. This is the case of 49-year-old woman with generalized subarachnoid neurocysticercosis associated to encephalic and medullar compromise, a rare presentation of this neurotropic parasite, with seizures and severe motor limitation. Images showed generalized inflammatory response of the brain and spinal subarachnoid space, hydrocephalus and multiple calcified lesions, demonstrating and reaffirming the importance of neuroimaging tools for the clinical correlation and diagnosis of brain infectious diseases as neurocysticercosis with variability on the presentation and multiple central nervous system involvement.