SUMMARY The Tolosa-Hunt syndrome is an uncommon disease, described as an idiopathic granulomatous inflammation of the cavernous sinus or the superior orbital fissure. Its diagnosis is based on the presence of unilateral ophtalmoplegia associated with the enlargement and the enhanced contrast of the affected cavernus sinus in the MRI. We present the case of a 23-year-old man with ophthalmoplegia of the left eye, who was admitted to the Hospital Universitario del Valle. After performing extensive diagnostic studies, the Tolosa-Hunt syndrome was considered the cause of symptoms.KEY WORDS. Epilepsy, Tolosa-Hunt syndrome, Painful Ophthalmoplegia, Sinus cavernous syndrome, Steroids (MeSH).. Recibido: 15/06/14. Aceptado: 3/10/14. Correspondencia: David Aguirre : davidaguirremd@gmail.com (1) David Alejandro Aguirre V, Residente de Medicina Interna Universidad del Valle, Hospital Universitario del Valle.(2) Gonzalo Zuniga, Medico Neurologo, Profesor Titular, Facultad de Medicina, Departamento de Medicina Interna, Universidad del Valle.(3) Lena Isabel Barrera, Medica Internista, Magister en Epidemiologia, Docente asociado Departamento de Medicina Interna Universidad del Valle, Hospital Universitario del Valle.