Volatile fractions and essential oils obtained from the flowers and leaves of Cyanthillium cinereum, isolated by simultaneous-distillation extraction (SDE) and conventional hydrodistillation (HD), were analyzed by gas chromatography and mass spectrometry (GC-MS). The most abundant compounds found in the volatile fractions were: (a). flowers – -cadinol (14.4%), δ-cadinene (11.0%), thymohydroquinone dimethyl ether (7.0%), -humulene (6.4%), -muurolol (5.8%), and terpinen-4-ol (5.1%); and, (b). leaves – -cadinol (20.3%), δ-cadinene (11.7%), germacrene D-4-ol (9.1%), -muurolol (6.5%), terpinen-4-ol (5.8%), and elemol (5.1%). As main compounds in the essential oils (EO) were identified: (c). flowers – δ-cadinene (15.8%), -cadinol (15.7%), -humulene (9.6%), -muurolol (6.1%), thymohydroquinone dimethyl ether (5.5%), and -cadinol (4.4%); and, (d). leaves – -cadinol (23.2%), elemol (10.6%), cadinene (9.9%), -muurolol (8.2%), germacrene D-4-ol (6.1%), and terpinen-4-ol (4.9%). The yield achieved in the isolation of EO was 0.09%, for the flowers and leaves. Similarly, volatile fractions and essential oils, classified according to the terpene structures and chemical functionality, were represented by cadinane type sesquiterpene bicyclic hydrocarbons (19.8-30.9%) and their alcohols (36.2-46.2%).