21 year old male with bullous lesions in more than 30% of total body surface (TBS), history of sulpha intake 15 days before the symptoms onset. The diagnosis was toxic epidermal necrolysis (TEN) and treatment pentoxiphiline and hydroelectrolitic was started, with satisfactory evolution without complications. This case is especially interesting considering the non general consensus at present regarding this entitys management and the very favorable results of pentoxiphiline, as a high cost-effective therapeutic option in our country.