Unintentional injuries constitute an important proportion of the global burden of disease for the elderly. A larger part of the accidents are potentially preventable, so that it is necessary to establish effective measures to avoid them and to stop their dreadful outcomes. This article reviews this aspect, to evaluate the problem impact, the risk factors, and several targeted multidimensional and multifactorial interventions to prevent injuries among older people, as a tool for our daily medical practice in order to build a complete risk profile to intervene this problem with interdisciplinary approaches.