The present research explored the interactional patterns of four families with a member with schizophrenia in a process of systemic therapy. The purpose of this investigation was to identify differences and similarities in the interactional patterns of these families and how these patterns change depending on the time course of the condition. It also sought to investigate what healing patterns have this families and what kind of interactions in therapy promote a change in the processes and which not. This research is a case study framed within the Research-Intervention. The methodology used was qualitative. The sources of data collection for this study were the therapy sessions taped and later transcribed. The data analysis was performed using the method of categorization and triangulation with the help of the program Atlas.ti. The research results point to two interactional patterns common to all cases, these are: Invisibility and Impasse partner. In turn it is evident that there is a change in the patterns of interaction in different stages of the disorder as well as a profound impact of these patterns in the family. It was also clear how these patterns are interwoven with each other and how over time they configure complex and harmful interactional dynamics. Finally it became clear the importance of initiating a process of therapy as soon as possible, as this prevents the family is organized around the symptom.