Objectives: Identify strong predictors of smoke consumption by teenagers of high school Santiago of Cali. Materials and methods: Cross-sectional study with a sample of 286 adolescents enrolled and assets from 6 to 9 degree in school year 2005. From the prevalence of smoke consumption was estimated to differences with the independent variables with Ji2 and P values. The predictive factors were established with a logistic model not conditional upon assessment of confusion and colineality. Results: The prevalence of consumption was 40,5% [CI: 34,8-46,4]. In all three models, consumption of friends had an OR 2,31, 95%[CI: 1,06-5,04]; smoking if a friend is what gives was OR 7,45, 95% [CI 3,9-14,0] and exposure to cigarette smoke explain consumption with an OR 2,18 95% [CI:1,23-3,87]; Hosmer Lemeshow Ji2 Test =10,60 and P Value =0,2253. Conclusions: In this group of teenagers just as friends were possible predictors of the consumption of tobacco, although there was some consumption by parents was not statistically significant, if it was for exposure to smoke outside the home. There were no associations with alcohol or psychoactive substances.