Abstract Peutz-Jeghers syndrome is characterized by hamartomatous polyps primarily located in the small intestine. Most of these patients undergo several endoscopic or surgical resections. This study reports the case of a -tion of polyps. Keywords Peutz-Jeghers, double balloon enteroscopy, laparoscopy. INTRODUCTION Hamartomatous polyptous polyposis syndromes cons-titute a group of at least six different rare diseases that require endoscopic management. Although there are no prospective surveys available that would prove the validity of therapeutic approaches, knowledge of genetic bases and pathological manifestations of these diseases can be used to adapt interventional and monitoring approaches for affec-ted patients (1).Hamartomatous polyptous polyposis syndromes include juvenile polyposis, Bannayan-Riley-Ruvalcaba Syndrome, Peutz-Jeghers Syndrome, Cowden disease and a few mixed polyposis syndrome which are characterized by adenomas, hyperplasic polyps and other lesions (1).Peutz-Jeghers syndrome is an autosomal dominant con-dition characterized by the development of hamartoma-tous polyps throughout the gastrointestinal tract which are associated with mucocutaneous pigmentation (2).Classic surgical management with multiple enterotomies and polyp removal has been replaced in recent years by endoscopic surgery.The endoscopic surgery performed on this patient will be explained in the review.