This article considers the socioeconomic determinants of infant mortality in Colombia, by using the most recent and available census to the public data in Colombia (1993). For such aim, the Infant Mortality Rate (IMR) is calculated by indirect estimation techniques following the Brass-Trussell method, given the high rates of sub-registry, which can reach 30%. These estimations allow better measurements of IMR by different socioeconomic characteristics, never measured before in Colombia, as well as to apply a statistical model that parametrically measures the main socioeconomic determinants of the IMR. The results prove maternal education, predominant housing materials, access to public and sanitary services to be the main determinants of IMR in Colombia.