This article proposes the High Performance Liquid Chromatography as an alternative to realize the follow up of the weak acids with strong bases titrations. Taking advantage of the kindness of this powerful instrumental technology it is possible to visualize in real time all the substances involved in the process to quantify with extraordinary precision the variation of its concentration and to generate new graphs that allow analyzing the advance of the neutralization process from different perspectives. It is studied the titration case of the acetic one as weak monoprotic acid by a strong base, sodium hydroxide, applying a specific chromatographic method for organic acids.