Resumen Objetivo: Estudiar los patrones de expresion de los receptores de estrogenos, progestagenos y erb-2 en 85 pacientes atendidas en dos laboratorios de patologia de Barranquilla. De Julio del 2004 a diciembre del 2005. Material y metodos: Estudio Descriptivo de corte. Se utilizaron 85 muestras incluidas en parafina de pacientes con diagnostico de cancer de mama para lo cual, se realizaron estudios inmunohistoquimicos con tecnicas de peroxidasa – antiperoxidasa, se utilizaron anticuerpos monoclonales Dako contra estrogenos, progestagenos y ebr-2. Resultados: Se observo carcinoma in situ (4), cancer mesenquimal (1), carcinoma lobulillar (1) y resto carcinomas ductales infiltrantes grados I, II y III. La inmunohistoquimica mostro positividad para estrogeno y progestageno a nivel intracelular en 73 casos y negativos para erb-2, 11 fueron negativos para estrogeno y progestageno, uno fue positivo para ebr-2. Conclusiones: 1. El carcinoma ductal infiltrante grado II y III fue la forma histologica que se presento con mayor frecuencia (80) casos. 2. El 88,23 % de los casos fueron estrogeno y progestageno positivos. 3. La relacion entre el componente histologico y receptores hormonales positivos, sugieren buen pronostico. Palabras claves: Cancer de mama, receptores de estrogenos, receptores de progesterona, ERB-2. Abstract Objectives: To study the patterns of expression of the estrogen, progestagens and erb-2 receptors in 85 patients attended in two pathology laboratories from Barranquilla, from July 2004 to December 2005 Material and methods: This is a descriptive study of cohort. 104 cases were reviewed and 18 were excluded by lack of data. Inmunohistochemistry studies with techniques of peroxidase - antiperoxidase were made, for which Dako monoclonals antibodies against estrogens, progestagens and ebr-2 were used. Results: Four neoplasias were classified as carcinoma in situ, one mesenquimal cancer, one lobulillar carcinoma and the others were infiltrating ductal carcinomas grade I, II and III. The immunohistochemistry studies showed positivity for estrogens and progestagen at the intracellular level in 73 cases and negativity to erb-2, 11 were negative for both estrogen and progestagen and one was positive to ebr-2. Conclusions: 1.The infiltrating ductal carcinoma grades II and III were the histological presentation that appears most frequently (80) cases. 2. 88.03 % of the cases were positive for estrogens and progestagens. 3. The relation between the histological component and the hormonal receptors positivity, suggests a good prognosis. Key words: Breast cancer, estrogen receptors, progestagen receptors, ERB-2, prognosis.