This paper pretends to make an analysis of the impacts of Information and Communication Technologies in the strategic performance of enterprises, as well as analyze the challenges faced by managers to overcome old administrative paradigms and give way to new ways of thinking, leading and managing organizations, primarily those dealing with the clear definition of the business, choosing the competitive strategy, designing an aligned organizational architecture, building effective customers-business relationships and a renewed culture of continuous innovation as essential requirements to survive and thrive in this competitive world.