This article presents the design and implementation of a cross-curricular strategy at a state school in Colombia through the application of the Content and Language Integrated Learning (CLIL) approach. The participants were 12 eleventh-grade students at “Instituto Tecnico Agricola Rafael Ortiz Gonzalez” and their Chemistry teacher. The decision of using CLIL approach relies on the provision of authentic input and teaching techniques that make learners interact meaningfully with new information, as a means of assisting them in the construction of knowledge. The English language was used as a vehicle for conveying messages that related to both, the usual interactions in the classroom and, comprehension and production of scientific discourse. The implementation of the strategy took 18 hours. In order to successfully promote the issues of Content, Cognition, Culture and Communication, the activities included authentic material, variety of exercises for the different stages of the lessons, a strong focus on health preservation and a considerable amount of opportunities for social interaction. Throughout the implementation of the lessons, students’ engagement in all the activities was noticeable and their Chemistry teacher played an outstanding role as a source of listening.