Introduction: In most cases of interstitial lung disease (ILD) and indeterminate pulmonary nodules, lung tissue is needed to achieve a precise a diagnosis. This study seeks to present the experience with lung wedge resections at a single institution. Materials and methods: Retrospective study of patients undergoing lung wedge resections for histopathologic study in the period 2004-2009 at Fundacion Oftalmologica de Santander – Clinica Carlos Ardilla Lulle in the city of Bucaramanga, Colombia,. Results: Fifty-two patients were operated on during this period. Twenty-eight (53.9%) were male; mean age was 60.5 years. Indications for surgery were nodules in 29 (55.8%) and ILD in 23 (44.2%). Patients with nodules presented more frequently without symptoms or findings at physical examination (p=0.008). In 88.5% and 76.9% of cases, the thoracoscopic technique was utilized and the number of resections was just one, respectively. Median operative time was 90min and it was shorter when the thoracoscopic technique was employed (p=0.04) and when a chest tube was not left in the pleural space (p=0.0006). A chest tube was not installed in 23.1% of cases. Median hospital length of stay was 2 days. Both morbidity and mortality were 5.8%, respectively. A precise diagnosis was achieved in 92% of patients. Conclusions: Lung wedge resection for ILD and indeterminate nodules is a safe procedure and can be done with a short length of stay. A chest tube can be omitted at the end of the procedure. In more than 90% of cases a precise diagnosis is achieved.