Seventeen patients suffering from Histoplasmosis were studied at Corporacion para Investigaciones Biologicas -CIB-Eight patients presented disseminated Histoplasmosis (DH), while another eight suffered from Chronic Pulmonary Histoplasmosis (CPH) and one presented a Histoplasmoma (H). Seventy five percent of the above mentioned patents exhibited systemic and respiratory symptoms, with persistent cough in 100% of the cases and hemoptoic expectoration in 87.3%. In half of the patients pulmonary calcifications were detected by X-Ray examination, while 25%showed nodular lesions In the DH form in the CPH form, 50% showed pulmonary calcifications and in the remaining 50% bullae was observed, 62.5% of them showed pulmonary fibrosis.