^les^aLa esplenectomia laparoscopica se ha convertido en el procedimiento estandar para resecar el bazo. Algunas series descriptivas han sugerido que la esplenectomia laparoscopica mano-asistida facilita la realizacion de este procedimiento en casos de esplenomegalia masiva. Objetivo: Describir la tecnica quirurgica de la esplenectomia laparoscopica mano-asistida como una opcion quirurgica que se considera de invasion minima. Caso: Paciente de sexo femenino de 65 anos con esplenomegalia masiva. Tecnica: Se inicio con una colecistectomia laparoscopica y luego se coloco el puerto de mano (Lap Disc® Johnson & Johnson) en incision de Pfannestiel. Los puertos laparoscopicos se ubicaron en ombligo, y dos subcostales izquierdos a 5 centimetros del borde del bazo. Con la mano dentro de la cavidad, se suspendio el bazo hacia la linea media y arriba para ligar los vasos polares y liberar las adherencias laterales. Posteriormente se aislaron digitalmente los vasos del pediculo y se ligaron con una endograpadora. Se libero el ligamento gastroesplenico con el bisturi armonico y se realizo hemostasia selectiva de los vasos cortos. El bazo se extrajo en una endobolsa y se realizo el cierre de los puertos.^len^aLaparoscopic splenectomy has become the standard procedure for resection of the spleen. Several series suggest that hand-assisted laparoscopic splenectomy facilitates the procedure in cases of massive splenomegaly. Objective. To describe the surgical technique of hand-assisted laparoscopic splenectomy as a minimally invasive surgical option. Case presentation. Sixty five-year old female with massive splenomegaly. Technique. We started with a laparoscopic cholecystectomy followed by the placement of a hand port (Lap Disc® Johnson & Johnson) in Pfannestiel incision. Laparoscopic ports were placed, one in the umbilicus, and two subcostal at 5 cm from the border of the spleen. With the hand within the abdominal cavity, the spleen was retracted toward the midline and cephalically so as to ligate the polar vessels and free lateral adhesions. We proceeded to digitally isolate the hylar vessels and ligate them with the endoligature. The gastrosplenic ligament was freed with the harmonic scalpel and selective hemostasis was performed. The spleen was extracted and the procedure was terminated with closure of the ports.