This study re analyzes the participation of bioethical issues involved in the conflicts that come out from the relationship between humans and wildlife, as a consequence of the smuggling in Colombia. This proposal of theoretical approach characterizes the trade of wildlife in the country. It also describes and analyzes some of the problems associated with this activity. The results showed that there is a lack of knowledge regarding ecosystem elements as well as the existing legislation in this matter. This causes an inappropriate use of the biotic resources. This study also found that the trade of goods from wildlife derived resources can contribute to have a more sustainable environment and to improve the living conditions of the communities involved. To obtain these benefits, it is necessary to develop strategies where the different participants get together and come out with an educational and joint plan that targets preventive measures.It is further proposed that the humanity is directly responsible for safeguarding and the proper use of wildlife, thus, ethical responsibility and authority in this regard should be shared by the human groups affected, as wells as the governmental institutions. This attitude aims to harmonize the conflictive relationship between humans and the biological resources, since this may be the only way to maintain ecosystemic balance and thereby protect the human communities associated. This approach will lead to the preservation of diversity not only in biological but also in cultural terms. Finally, we propose that an ethical intervention of current and future professionals is required, so they can make joint decisions in which the nonhuman world is also considered.