Se reporta el caso clinico de una paciente de quince anos de edad con maloclusion dental clase III, con deficiencia maxilar y prognatismo mandibular. La paciente consulto a edad temprana, por lo cual, se decidio esperar a que terminara su crecimiento y desarrollo para luego iniciar el tratamiento de ortodoncia con prescripcion de Alexander (Ormco) ® y hacer solamente cirugia mandibular (osteotomia oblicua de rama para retroceso), lograndose la adecuada relacion oclusal y balance facial. Se siguio el protocolo de atencion de ortodoncia y cirugia maxilofacial para los pacientes tratados en los posgrados de Odontologia Integral del Adolescente y Ortodoncia y el posgrado de Cirugia Oral y Maxilofacial de la Facultad de Odontologia de la Universidad de Antioquia. ABSTRACT. A clinical case report of a fifteen year old female with an Angle class III malocclusion and with maxillary deficiency and mandibular prognathism is presented. The patient initially consulted at an early age and a decision was made to delay comprehensive treatment until her skeletal growth ended. Alexander’s prescription (Ormco) was used for orthodontic treatment and a mandibular surgical set back only with oblique ramous osteotomy was performed achieving an adequate occlusal relationship and facial balance. This patient was treated according to the protocol established for the orthodontic and oral and maxillofacial surgery postgraduate programs of the Dental Faculty of the University of Antioquia