The concept of information has acquired a substantial power in biology, becoming the mayor metaphor of modern biology. This has allowed the development of disciplines such as recombinant DNA technology, transgenic organisms, genome sequencing, and what we now call biotechnology. Yet its birth was much humbler and did not encompass so many options. The concept of information in biology could achieve a much-refined stance than just the equivalent of genetic information by enlarging its conceptual scope, not limited to molecular terms but dealing with higher levels of organization. It is intended here to lay the bases for an updated comprehension of information, widening its perspective within this land of hi-fi and HD that biology has become. Key words: Information, genetic program, digital information, positional information, structural information, complementarity, biosemantics.