OBJETIVOS: Sugerir un esquema de decision para la fijacion de precios de medicamentos incluidos en el Regimen de Libertad Regulada, RLR, una modalidad de regulacion de la politica de precios de medicamentos en Colombia. El esquema sugerido incluye dos herramientas metodologicas, los Precios Internacionales de Referencia, PIR, y los Analisis de Costo Minimizacion, ACM.METODOLOGIA: Acorde con la politica de precios vigente, se construyeron los precios internacionales de referencia con el promedio de los tres precios mas bajos con datos de 5 paises para 18 medicamentos del RLR. Por otro lado, el ACM se basa en seleccionar los medicamentos de RLR con posibles comparadores, seleccionar los medicamentos comparadores y evaluar los costos del tratamiento. El esquema de decision para la fijacion de precios de medicamentos del RLR se basa en la estimacion del PIR, el ACM e identifica los posibles desenlaces.RESULTADOS: De la estimacion de los PIR, se obtiene que 12 de los 18 medicamentos tienen en el mercado farmaceutico local un precio mayor a sus respectivo precio de referencia. Por otro lado, se diseno un esquema de decision que puede ser util para asistir la regulacion de precios del RLR en Colombia.CONCLUSIONES: Como muestran los resultados, los precios internacionales de referencia permiten observar cuando los precios de un pais son mayores a los de paises de referencia. En la politica de precios de medicamentos vigente en Colombia, la estimacion del PIR ha sido aplicada para seis medicamentos. Podria ser apropiado extender esta metodologia a otros medicamentos de alto impacto en el gasto farmaceutico, especialmente si su cobertura es con recursos publicos. La disponibilidad de fuentes primarias sobre costos de tratamiento en Colombia debe mejorarse para desarrollar evidencia farmacoeconomica. El SISMED representa una importante fuente primaria de precios de medicamentos, sin embargo, este sistema de informacion requiere ser mejorado en la calidad y disponibilidad de la informacion.OBJECTIVES: To suggest a scheme of decision making on pricing for medicines that are part of Free Regulated Regime, a regulation way of the pharmaceutical pricing policy in Colombia. The suggested scheme includes two regulation tools international reference prices and a cost minimization analysis methodology. METHODS: Following the current pricing policy, international reference prices were built with the average of the three lower prices with data from 5 countries for 18 medicines which are under Free Regulated Regime. The cost minimization analysis methodology includes selection of those medicines under Free Regulated Regime with possible comparable medicines, selection of comparable medicines, and treatment costs evaluation. The scheme of decision making on pricing for medicines that are part of Free Regulated Regime includes estimation of the international reference prices and cost minimization analysis methodology, it identifies also every possible decision outcomes. RESULTS: As a result of the international reference prices estimate, twelve of eighteen medicines showed in the domestic pharmaceutical market a price bigger than the reference price.A scheme of decision-making was design containing two possible regulation tools for medicines that are part of Free Regulated Regime, international reference prices estimation and cost minimization analysis methodology. This diagram would be useful to assist the pricing regulation of Free Regulated Regime in Colombia.CONCLUSIONS: As present results shows, international reference prices make clear when domestic prices are higher than those of reference countries.In the current regulation of pharmaceutical prices in Colombia, the international reference price estimation has been applied for six medicines. Would be suitable to extend this methodology to other medicines of high impact on the pharmaceutical expenditure, in particular those covered by public funding.The availability of primary sources about treatment costs in Colombia needs to be improve as a requirement to develop of pharmaco-economic evidence. SISMED is an official database that represents an important primary source of medicines prices in Colombia. Nevertheless, having into account that SISMED represents an important advantage of transparency in medicines prices, it needs to be improve in quality and availability of data.