This article intends to place the topic of human development and quality of life within the urban problematic in Barranquilla, Colombia, and the urgent necessity to meet some habitability and convivential criteria, within a sustainable development framework. In order to accomplish this, health problems and their relationship with the urban space in the city are described, next the concept of Human Development and Quality of Life, and habitability in Barranquilla are presented. It finishes suggesting a new perspective of analysis which coherently integrates all the afore said to the sustainability concept, as an alternative to generate better quality of life, higher human development and higher habitability in the city.