Schizophrenia is defined as a severe chronic mental disorder. One of his distinctive features is the deficit in the social and interpersonal functioning, affecting more than 6 million people in Latin America. Today, the treatment of schizophrenia is based on the combined use of antipsychotic medications and psychosocial therapies, such as psychoeducational family interventions, social skills training and cognitive-behavioral treatments. However, if these rehabilitation therapies have positive effects, we don’t know yet how they. Besides, few studies have been published that validate empirically these programs in the Latin American context. The challenge lies in identifying the essential components of social cognition. Recently, a new theoretical approach, the Relational Frame Theory has proposed a functional analytic conceptualization of both verbal behavior and social cognition. This approach suggests that the deficits in terms of social cognition are at the level of basic verbal processes (relational responses) and not in the knowledge of the social rules. This research evaluate and compare the effect of two types of therapeutic interventions on social cognition in people with schizophrenia; the first intervention is a classical social skills training while the second aimed at developing derived relational responding based on deictic frames, with a cross-sectional multiple treatments group design, pre and post-test, and follow-up at 1 month. The results show a significant effect of these two therapeutic approaches on the Hinting Task scores, and positive but not significant on social anhedonia and social functioning scales.