Introduction: the idea to explore at least some of the regions diversity such as the Colombian Orinoco through bioprospecting study of Lacmellea standleyi (Woodson) Monach. arises as a consequence of ignorance of much of the floristic richness in Colombia and the potential relevance of much of this in the nutrition, health and industry. Objective: to evaluate the antioxidant potential, nutritional and phenolic content, antimicrobial activity, and safety degree of aqueous, ethanol, and ethyl acetate extracts of Lacmellea standleyi fruits in three different ripening stages. Methods: the nutritional value was evaluated using standardized methods to full fruit in its three ripening stages. Each of the extracts was chemically characterized by spectrophotometric assays. Antimicrobial activity was measured by the size of inhibition against strains of Staphylococcus aureus, Escherichia coli, and Candida parpsilosis; the acute toxicity of the fruits was measured through in vitro tests using Artemia salina as experimental model. Results: the results show that green fruits are suppliers of antioxidant compounds. Higher levels of nutrients are found in the intermediate state and mature fruit has attractive organoleptic properties and a relatively high nutrient content. Conclusions: the antioxidant capacity of Lacmellea standleyi fruits was evident in the three ripening stages, giving the plant a promising future in the pharmaceutical industry, standing out in this field the fruits in the green stage. Furthermore, the results suggest the application of the intermediate and mature fruits in the finished products development. The safety observed in the plant material warrants its use in human consumption.