This paper analyzes, through case study, the activity of the Colombian Caribbean entrepreneurs in the inland country during the 19th century. It discusses the business of Amador family, Juan Bautista Mainero and Fergusson Noguera family. The aim is to highlight the importance of studying the interregional phenomena, evidencing the existence of national spheres for large business in the 19th century. Thus, it provides elements for a better understanding of the historical process of Colombian economic integration.