El granuloma periferico de celulas gigantes (GPCG) es una lesion pseudotumoral exofitica poco frecuente en cavidad oral, localizado principalmente en el maxilar inferior en zona de premolares y molares, sangrante y de crecimiento rapido, asociado a factores irritativos o agresion (extraccion, traumatismo, placa, sarro, obturacion desbordante, infeccion cronica, impactacion alimentaria, etc.). Su tratamiento es la excision quirurgica, retirando los factores irritativos. Dentro de sus diagnosticos diferenciales se encuentran el tumor pardo del hiperparatiroidismo, el querubismo y el quiste oseo aneurismatico, que tienen el mismo patron histologico del granuloma periferico de celulas gigantes. Se reporta caso clinico de paciente femenino de 52 anos de edad que acudio a consulta odontologica en la Facultad de Odontologia de la Universidad de Cartagena, por presentar una lesion tumoral ubicada en encia vestibular y lingual zona de anteroinferiores asociada con abundante placa bacteriana y calculos subgingivales. Se le realizo la escision quirurgica de la lesion, exodoncia de los dientes involucrados por la marcada perdida osea, curetaje y se envio a patologia donde se confirmo diagnostico de granuloma periferico de celulas gigantes. ABSTRACT. The peripheral giant cell granuloma (PGCG) is a pseudotumoral exophytic lesion, very rare in oral cavity, it is primarily located in the premolar and molar area of the mandible, it usually presents bleeding and rapid growth, also, is associated with aggression or irritating factors (extraction, trauma, plaque, tartar, faulty restorations, chronic infection, food impaction, among others). Its treatment consists of surgical excision, removing the irritating factors. Within its differential diagnosis are the hyperparathyroidism brown tumor, cherubism and aneurysmal bone cyst, which have the same histological pattern as the peripheral giant cell granuloma. This is a description of a clinical case of a female patient, age 52 who attended the College of Dentistry of the University of Cartagena because she presented a tumor located in the vestibular and lingual gingival area of anterior and lower zone associated with abundant bacterial plaque and subgingival calculus. The surgeon made the surgical excision of the lesion, extraction of teeth affected by the marked bone loss, and curettage. The sample was sent to the pathology lab which confirmed the diagnosis of peripheral giant cell granuloma.